Hideto ITO

【Education & Experience】 
2003.4–2007.3:         Undergraduate Student
    Department of Chemistry, Graduate School of Science, Hokkaido University (Prof. Masaya Sawamura)
2007.4–2009.3:         Graduate Student (Mater Course)
    Department of Chemistry, Faculty of Science, Hokkaido University (Prof. Masaya Sawamura)   
2009.4–2012.3:         Graduate Student (Doctor Course)
    Department of Chemistry, Faculty of Science, Hokkaido University (Prof. Masaya Sawamura)
2009.4–2012.3:         JSPS Research Fellow (DC1)
2010.3, 2010,10–12:  Visiting Researcher
Albert-Lüdwig Universitüt Freiberg (Prof. Barnhard Breit)
2012.4–2013.3:  JSPS Research Fellow (PD)
   Department of Chemistry, Graduate School of Science, Nagoya University (Prof. Kenichiro Itami)  
2013.4–2018.8:  Lecturer
   Liberal Arts and Sciences, Nagoya University
2018.4–present:  Associate Professor
    Department of Chemistry, Graduate School of Science, Nagoya University

Others
2013.7–present:  Collaborating Investigator
   Institute of Transformative bio-Molecules (WPI-ITbM), Nagoya University
2017.11–2020.03: Sub-group leader
Itami Molecular Nanocarbon Project, JST-ERATO

2009: Best Disccussion Award, 21th Banyu Sapporo Symposium
2010: Otsu Conference Fellow (No.001)
2012: Ikushi Prize, JSPS
2015: Liberal Arts and Sciences Education Award, Nagoya University
2015: SHOWA DENKO Award in Synthetic Organic Chemistry, the Society of Synthetic Organic Chemistry, Japan
2016: Wakashachi Incentive Research Award, Grand Prize
2017: Synlett Best Paper Award 2016 (with Prof. K. Itami, Y. Segawa, Mr. Y. Yano)
2017: Verder-Scientific Award (IRMAIL Science Grant)
2018: the 32nd Chemical Society of Japan Lecture Award for Young Chemists, Chemical Society of Japan
2018: The PCCP prize 2018, Chemical Society of Japan & Royal Society of Chemistry
2019: The 68th Chemiscal Society of Japan Award for Young Chemists  
2019: Akasaki Award, Nagoya University）
2020: The 2020 Early Career Advisory Board of ACS Catalysis
2023: Banyu Chemist Award (BCA), MSD Life Science Foundation
2023: The 28th Young Researcher Award, Society of Silicon Chemistry, Japan (SSCJ)
2024: 2024 Thieme Chemistry Journals Award
2025: Organic Chemistry Frontiers Outstanding Paper Award 2014-2023 (RSC & CCS)

Organometallic Chemistry, Synthetic Organic Chemistry, Polymer Chemistry, Nanocarbon Science

see a full publication list

[16] Birch Reductive Arylation by Mechanochemical Anionic Activation of Polycyclic Aromatic Compounds
Yoshifumi Toyama, Akiko Yagi, Kenichiro Itami,* Hideto Ito*
ChemRxiv. Aug 30th, 2024. DOI: 10.26434/chemrxiv-2024-ts4vf
Nat. Commun. 2025, 16, 5044.
Press release (JP): https://www.nagoya-u.ac.jp/researchinfo/result/2025/06/post-841.html
Press release (EN): https://www.nagoya-u.ac.jp/researchinfo/result-en/2025/06/20250618-01.html

[15] Rh-catalyzed mechanochemical transfer hydrogenation for the synthesis of periphery-hydrogenated polycyclic aromatic compounds
Yoshifumi Toyama, Takumu Nakamura, Yushin Horikawa, Yuta Morinaka, Yohei Ono, Akiko Yagi, Kenichiro Itami,* Hideto Ito*
ChemRxiv. Feb. 25th, 2025. DOI: XXXX.
Chem. Sci. 2025, 16, 9117–9124. DOI: 10.1039/D5SC01489A. [detail]
Press Release (JP): https://www.nagoya-u.ac.jp/researchinfo/result/2025/04/post-811.html
Selected as an Inside Cover Picture: https://pubs.rsc.org/en/content/articlelanding/2025/sc/d5sc90115d

[14] Functionalization and solubilization of polycyclic aromatic compounds by sulfoniumization
Johannes E. Erchinger,# Tsubasa Okumura,# Kanami Nakata, Daisuke Shimizu, Constanstin G. Daniliuc, Kazuma Amaike,* Frank Glorius, Kenichiro Itami* and Hideto Ito*
Chem. Sci. 2025, 16, 8262–8267. DOI: 10.1039/D5SC01415H. [detail]
# Equally contributions.
Selected as a back inside cover picture: https://pubs.rsc.org/en/content/articlelanding/2025/sc/d5sc90107c
Press Release (JP): https://www.nagoya-u.ac.jp/researchinfo/result/2025/04/post-810.html

[13] Synthesis of Heptagon-Containing Polyarenes by Catalytic C–H Activation
Keigo E. Yamada, Iain A. Stepek, Wataru Matsuoka, Hideto Ito,* Kenichiro Itami*
Angew. Chem. Int. Ed. 2023, 62, e202311770. DOI: 10.1002/anie.202311770. [detail]
Highlighted in Synfacts 2024, 20, 0255. DOI: 10.1055/s-0043-1773027

[12] Expanded [2,1][n]Carbohelicenes with 15- and 17-Benzene Rings
Michihisa Toya, Takuya Omine, Fumitaka Ishiwari, Akinori Saeki, Hideto Ito,* Kenichiro Itami*
Submitted to ChemRxiv. DOI: 10.26434/chemrxiv-2023-k9pzj
J. Am. Chem. Soc. 2023, 145, 11553–11565. DOI: 10.1021/jacs.3c00109 [detail]

[11] Lithium-mediated mechanochemical cyclodehyrogenation
Kanna Fujishiro, Yuta Morinaka, Yohei Ono, Tsuyoshi Tanaka, Lawrence T. Scott, Hideto Ito,* and Kenichiro Itami*
Submitted to ChemRxiv. DOI: 10.26434/chemrxiv-2023-k4z34
J. Am. Chem. Soc. 2023, 145, 8163–8175. DOI: 10.1021/jacs.3c01185 [detail]
Nagoya University Press Release: https://www.nagoya-u.ac.jp/researchinfo/result/2023/04/post-482.html

[10] One-step synthesis to polycyclic thianthrenes from unfunctionalized aromatics by thia-APEX reaction
Kou. P. Kawahara, Hideto Ito,* Kenichiro Itami*
Org. Chem. Front., 2023, 10, 1880–1889. Open Access. DOI: 10.1039/D2QO02058K [detail]
Organic Chemistry Frontiers Emerging Investigator Series, 2023.
Selected as a cover art picture in vol. 10, issue 8 in Org. Chem. Front.

[9] Rapid access to polycyclic thiopyrylium compounds from unfunctionalized aromatics by thia-APEX reaction
Kou. P. Kawahara, Hideto Ito,* Kenichiro Itami*
Chem. Commun. 2023, 59, 1157–1160. DOI: 10.1039/D2CC06706D. [detail]

[8] π-Extended Rubrenes via Dearomative Annulative π-Extension Reaction
Wataru Matsuoka, Kou P. Kawahara, Hideto Ito,* David Sarlah, Kenichiro Itami*
J. Am. Chem. Soc. 2023, 145, 658-666. DOI: 10.1021/jacs.2c11338.[detail]

[7] Infinitene: A Helically Twisted Figure-Eight [12]Circulene TopoisomerMaciej Krzeszewski, Hideto Ito,* Kenichiro Itami*
Submitted. ChemRxiv DOI: 10.33774/chemrxiv-2021-pcwcc [link] [detail]
J. Am. Chem. Soc. 2022, 144, 862–871. DOI: 10.1021/jacs.1c10807
Highlighted in Chemistry Views [link], C&En News [link]
Selected as “The Molecules of The Year 2021” by C&En News, ACS [link] [detail]
Selected as a Supplementary Cover Picture in vol 144 issue 2.
One of most cited publications from 2021–2022 (Sep. 14th, 2023).[detail]

[6] Diversity-oriented synthesis of nanographenes enabled by dearomative annulative π-extension
Wataru Matsuoka, Hideto Ito,* David Sarlah,* Kenichiro Itami*
Nature Commun., 2021,12, 4940. DOI: 10.1038/s41467-021-24261-y [Detail]

[5] Synthesis of Nitrogen‐Containing Polyaromatics by Aza‐Annulative π‐Extension of Unfunctionalized Aromatics
Kou P. Kawahara, Wataru Matsuoka, Hideto Ito*, Kenichiro Itami*
Angew. Chem. Int. Ed. 2020, 59, 6383-6388. DOI: 10.1002/anie.201913394 【detail】

[4] C-H Arylation of Phenanthrene with Trimethylphenylsilane by Pd/o-Chloranil Catalysis: Computational Studies on the Mechanism, Regioselectivity, and Role of o-Chloranil
Mari Shibata, Hideto Ito,* Kenichiro Itami*
J. Am. Chem. Soc. 2018, 140, 2196–2205. DOI: 10.1021/jacs.7b11260【detail】

[3] Oxidative Homocoupling Reaction of Aryltrimethylsilanes by Pd/o-chloranil Catalysis
Mari Shibata, Hideto Ito,* Kenichiro Itami*
Chem. Lett.2017, 46, 1701–1704. DOI: 10.1246/cl.170723.【detail】

[3] Rapid Access to Nanographenes and Fused Heteroaromatics by Palladium-Catalyzed Annulative π-Extension Reaction of Unfunctionalized Aromatics with Diiodobiaryls
Wataru Matsuoka, Hideto Ito,* Kenichiro Itami*
Angew. Chem. Int. Ed. 2017, 56, 12224–12228. DOI:10.1002/anie.201707486 【detail】

[2]Construction of Covalent Organic Nanotubes by Light-Induced Cross-Linking of Diacetylene-Based Helical Polymers
Kaho Maeda, Liu Hong, Taishi Nishihara, Yusuke Nakanishi, Yuhei Miyauchi, Ryo Kitaura, Naoki Ousaka, Eiji Yashima, Hideto Ito,* and Kenichiro Itami*
J. Am. Chem. Soc. 2016, 138, 11001–11008. DOI: 10.1021/jacs.6b05582 【detail】【press release (JP)】[press release(EN)]

[1]. One-shot K-region-selective Annulative π-Extension for Nanographene Synthesis and Functionalization
Kyohei Ozaki, Katsuaki Kawasumi, Mari Shibata, Hideto Ito, and Kenichiro Itami
Nature Commun. 2015, 6, 6251. DOI: 10.1038/ncomms7251.【detail】
Highlighted in News Papers (Chunichi Shinbun, Nikkan Kogyo Shimbun, Zaikeishinbun)
   Highlighted in Science Portal, Scicasts, Phys Org, AZO NANO, nano werk, Science Daily, Asia Research News, Eurek Alert.

【Representative Reviews】

[4] Heteroatom-Embedding Annulative π-Extension (Hetero-APEX) Reactions – An Overview
Hideto Ito,* Kou. P. Kawahara, Kenichiro Itami*
Synthesis, in press. DOI: 10.1055/a-2169-4078 [detail]

[3] Construction of Heptagon‐Containing Molecular Nanocarbons
Chaolumen, Iain A. Stepek, Keigo E. Yamada, Hideto Ito,* Kenichiro Itami*
Angew. Chem. Int. Ed., 2021, 60, 23508–23532. https://doi.org/10.1002/anie.202100260

[2] Polycyclic Arene Synthesis by Annulative π-Extension
Hideto Ito, Yasutomo Segawa, Kei Murakami, Kenichiro Itami*J. Am. Chem. Soc. 2019, 141, 3-10. DOI: 10.1021/jacs.8b09232 【detail】

[1] Annulative π-Extension (APEX): An Enabling Reaction for Rapid Access to Fused Aromatics, Heteroaromatics, and Nanographenes
Hideto Ito,* Kyohei Ozaki, and Kenichiro Itami*
Angew. Chem. Int. Ed. 2017, 56, 11144–11164. DOI: 10.1002/anie.201701058.【detail】

【Research Grants】Grant Name (Grant Number), Foundation, Direct Cost
Principle Investigator:
FY2009-2011  Grant-in-Aid for JSPS Fellows (JP09J01922), Japan Society for the Promotion of Science, 2,100,000 JPY
FY2012  Grant-in-Aid for JSPS Fellows (JP12J30002), Japan Society for the Promotion of Science, 1,300,000JPY
FY2014-2016  Grant-in-Aid for Encouragement of Young Scientists (B) (JP26810057), Japan Society for the Promotion of Science, 3,100,000JPY
FY2014-2015  Grant for Japan-Related Research Project, Sumitomo Foundation, 1,300,000JPY
FY2016-2017 Grant-in-Aid for Scientific Research on Innovative Areas (JP16H00907), Science of Atomic Layer Systems, Japan Society for the Promotion of Science, 3,200,000 JPY
FY2016 Showa Denko Award in Synthetic Organic Chemistry, Japan, 500,000 JPY
FY2017 Wakashachi Incentive Award Grand Prize, 300,000JPY
FY2018 Daiko Foundation, 4,000,000 JPY
FY2017-2019 Grant-in-Aid for Challenging Research (Exploratory) (JP17K19155), Japan Society for the Promotion of Science, 5,000,000JPY
FY2018–2020 Grant- in-Aid for Scientific Research (B) (18H02019), Japan Society for the Promotion of Science, 13,700,000JPY
FY2020-2021 Grant-in-Aid for Challenging Research (Exploratory) (JP20K21192), Japan Society for the Promotion of Science, 5,00,000JPY
FY2021 Grant- in-Aid for Scientific Research (B) (21H01931), Japan Society for the Promotion of Science, 4,500,000JPY
FY2025–2027 Grant-in-Aid for Transformative Research Areas (B) Ladder Polymer Science: Innovation through Ladder Bonding (25H01408), Japan Society for the Promotion of Science, 20,700,000 JPY
FY2025–2028 Grant- in-Aid for Scientific Research (B) (25K01764), Japan Society for the Promotion of Science, 14,500,000JPY

Co-Principle Investigator:
FY2025–2027 Grant-in-Aid for Transformative Research Areas (B) Ladder Polymer Science: Innovation through Ladder Bonding (25H014006), Japan Society for the Promotion of Science, 11,400,000 JPY

Co-Investigator
FY2020-2021 Grant-in-Aid for Specially Promoted Research (PI: Hirokazu Kawagishi) (JP20H05620), Science of fairy chemicals and their application developement
FY2019-2021 CREST (PI: Hajime Ito), Japan Science and Technology Agency (JST)

【Classes】
From FY2019–present
Organic Chemistry III (Spring, Mon. 2nd period, 3rd year undergraduates)
Organic Chemistry Laboratory Experiments (Spring, 3rd year undergraduates)
Current Organic Chemistry (Spring, G30 course)
Advanced Organic Chemistry II (Fall, Fri. 2nd period, 3rd year undergraduates)
Chemistry Seminar III (Fall, Tue. 3rd period, 2nd year undergraduates)
Organic Chemistry Seminar I-IV (1st and 2nd year graduates)

Previous Teachng Experience
FY2020–2023
First Year Seminar A: “Pseudo Science revealed by Chemistry” (Spring, Mon. 4th period, 1st year graduate)
FY2019:
Materials and Chemistry (Fall, 1st year undergraduates
FY2013–2018:
Chemistry in Labotaroty (Spring, Wed. 3rd and 4th periods (G30), Thu. 4th and 5th periods (Faculty of Engineering), Fri. 4th and 5th periods (Faculty of Engineering); Fall, Tue. 3rd and 4th periods (Faculty of Science), Fri. 4th and 5th periods (Faculty of Agriculture)